Intermembrane Sphingolipid Transport Sphingolipids are unevenly distributed in different subcellular membranes and, as described above, in the single membrane as well. The heterogeneous distribution of complex sphingolipids in the different subcellular membranes, varying from 3-4% of total membrane lipids in the ER to about 20 mol % in the PM and lysosomes,84 strongly reflects the […]
Abstract Sphingolipid (SPL) metabolism (Fig. 1) serves a key role in the complex mechanisms regulating cellular stress responses to environment. Several SPL metabolites, especially ceramide (Cer), sphingosine (Sph) and sphingosine1-phosphate (S1P) act as key bioactive molecules governing cell growth and programmed cell death (Fig. 2). Perturbations in sphingolipids of one type may enhance or interfere […]