Environmental Engineering Reference
In-Depth Information
H
3
C
O
H
3
C
N
H
H
3
C
CH
3
O
(a)
H
O
scherellin A, B
(b)
FISCHERELLA AMBIGUA
(KUTZING EX BORNET
& FLAHAULT) GOMONT, 1895
Phylum: Cyanobacteria Class: Cyanophyceae
Order: Nostocales Family: Hapalosiphonaceae
Distribution: Asia, Australia, New Zealand, Paciic Islands, United States,
Canada, Mexico, Iran
Habitat: Freshwater habitats, submerged substrata, paddy ields
Description: This species has uni- and multiserial ilaments. The trichomes are
moniliform and creeping. The cells of the ilaments are with granules. The
heterocysts in the basal trichomes are subspherical, but the heterocysts of
the branches are cylindrical.
Compounds and activities: The bioactive compound, isherindole L, isolated
from this species has shown antifungal properties. Other compounds isolated
from this species include parsiguine, ischambiguines A and B, ambiguine
P, ambiguine Q nitrile, ambiguine G nitrile, and hapalindole-related alka-
loids. Among them, ischambiguines A and B have shown inhibitory activi-
ties against
Mycobacterium tuberculosis
. The petroleum ether fraction of
this species has, however, shown antibacterial activities particularly against
Escherichia coli
. Its ambiguine K and M isonitriles have also shown most
potent activity against
M. tuberculosis
, with minimum inhibitory concen-
tration (MIC) values of 6.6 and 7.5 μM, respectively. Ambiguine A isoni-
trile has shown the most potent activity against
Bacillus anthracis
with a
MIC of 1.0 μM (Mo et al.,
2009). The novel compound parsiguine has been
reported to show antimicrobial properties (Shokravi et al., 2004).
