Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool - Intracellular Delivery: Fundamentals and Applications - page 143

Table 3 Transition elements and initial concentrations of the model
Number of process Process rate Equilibrium Rate determining components Decreasing components Increasing components

Formation
R2

0.05 100000 pm_NV_L_D, pm_R pm_NV_L_D, pm_R pm_NV_L_D_R

R14 0.05 100000 cyt_NV_L, cyt_Mot cyt_NV_L, cyt_Mot cyt_Mot_NV_L

R19 0.01 100000 cyt_NV_D, cyt_Mot cyt_NV_D, cyt_Mot cyt_Mot_NV_D

R31 0.05 100000 cyt_NV, cyt_Mot cyt_NV, cyt_Mot cyt_Mot_NV

Formation with transport
R25 0.0005 100000 ext_NV_L_D, pm_Lip ext_NV_L_D, pm_Lip pm_Lip NV_L_D

Transport
R1 0.005 100000 ext_NV_L_D ext_NV_L_D pm_NV_L_D_R

R3 0.05 100000 pm_ NV_L_D_R pm_ NV_L_D_R ee_ NV_L_D_R

R5 0.01 100000 ee_ NV_L_D_R ee_ NV_L_D_R lys_NV_L_D_R

R7 0.1 100000 ee_ NV_L_D ee_ NV_L_D le_ NV_L_D

R8 0.01 100000 le_ NV_L_D le_ NV_L_D lys_ NV_L_D

R10 0.1 100000 le_ NV_L_D le_ NV_L_D cyt_ NV_L_D

R15 0.05 100000 cyt_ Mot_NV_L cyt_Mot NV_L pm_Mot_NV_L

R17 0.05 100000 pm_Mot pm_Mot cyt_Mot

R18 0.05 100000 pm_NV_L pm_NV_L ext_NV_L

R20 0.01 100000 cyt_Mot_NV_D cyt_Mot_NV_D pm_Mot_NV_D

R22 0.05 100000 pm_NV_D pm_NV_D ext_NV_D

R24 0.0001 1000 ext_NV_L_D ext_NV_L_D cyt_NV_L_D

R32 0.01 100000 cyt_Mot_NV cyt_Mot_NV pm_Mot_NV

R34 0.05 100000 pm_NV pm_NV ext_NV

R35 0.0001 1000 ext_NV ext_NV cyt_NV

R36 0.0001 1000 ext_NV_L ext_NV_L cyt_NV_L

R37 0.0001 1000 ext_NV_D ext_NV_D cyt_NV_D

(continued)