DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 688

TABLE 22.4. ( Continued )

Flavonoid Cell Line Used Substrates Effect on Pgp Refs.

Flavonols
Fisetin

Panc-1 cells (MRP1)
MDCK-MRP1
MDCK-MRP2

DNM/VBL
Calcein
Calcein

↓ Accumulation
↔ Efflux
↔ Efflux

32
162

Galangin Panc-1 cells (MRP1) DNM

VBL
DNP-SG
Calcein
Calcein

↓ Accumulation
↔ Accumulation
↓ Efflux via MRP1
↓ Efflux
↔ Efflux

32

MCF7-pMTG5 cells
MDCK-MRP1
MDCK-MRP2

161
162

Vesicles from GLC 4 /ADR cells
GLC 4 /ADR lung cancer cells/
membrane vesicles (MRP1)
Vesicles from HeLa-MRP1 cells

↑ ATPase activity
↑

185
183 Kaempferol Daunorubicin Accumulation

↑ ATPase activity

LT C 4 /E 2 17 G ↓ Transport

↔

146

Glutathione GSH transport

↑ ATPase activity

↑ ADP trapping
↑ Accumulation
↓ Efflux via MRP1
↓ Efflux
↔ Efflux

Panc-1 cells (MRP1)
MCF7-pMTG5 cells
MDCK-MRP1
MDCK-MRP2

DNM/VBL
DNP-SG
Calcein
Calcein

32
161
162

Morin Panc-1 cells (MRP1) DNM/VBL ↑ Accumulation

↑ GSH level
↓ Efflux via MRP1
↓ Efflux via MRP1
↓ Efflux

32

MCF7-pMTG5 cells
Human erythrocytes
MDCK-MRP1

DNP-SG
BCPCF
Calcein

161
163
162