DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 689

Myricetin Vesicles from HeLa-MRP1 cells LT C 4

E 2 17 G
Glutathione
DNM
VBL
DNP-SG
Vincristine
Calcein

↓ Transport
↔ Transport
↑ GSH transport
↓ Accumulation
↔ Accumulation
↓ Efflux via MRP1
↓ Efflux
↓ Efflux

146

Panc-1 cells (MRP1) 32

MCF7-pMTG5 cells
MDCK-MRP1/2
MDCK-MRP1/2

161
186
162

Quercetin GLC 4 /ADR lung cancer cells (MRP1)

Vesicles from HeLa-MRP1 cells
Vesicles from HeLa-MRP1 cells

Daunorubicin
Glutathione
LT C 4 /E 2 17 G

↑ Accumulation
↑ GSH transport
↓ Transport
↓ ATPase activity
↑ ADP trapping
↑ MRP1 mRNA level
↑ Accumulation
↓

182
146,184
146

MCF-7 breast cancer cells
Panc-1 cells (MRP1)

187
32 DNM/VBL

GSH level

↓ Efflux via MRP1 161

188

MCF7-pMTG5 cells
Vesicles from human erythrocytes

DNP-SG
DNP-SG
cGMP
Calcein
BCECF
Calcein
Calcein

↓ Transport via MRP1

↓ Transport via MRP4

HEK293-MRP1
HEK293-MRP5
MDCK-MRP1
MDCK-MRP2

↑ Accumulation

↑ Accumulation
↓ Efflux
↔ Efflux

162

Rutin Panc-1 cells (MRP1) DNM

VBL

↔ Accumulation
↓ Accumulation

32