DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 687

TABLE 22.4. Interactions of Flavonoids with MRPs
Flavonoid Cell Line Used Substrates Effect on Pgp Refs.

Flavones
Apigenin GLC 4 /ADR lung cancer cells (MRP1)

GLC 4 /ADR lung cancer cells/
membrane vesicles (MRP1)
Vesicles from HeLa-MRP1 cells
Vesicles from HeLa-MRP1 cells
Panc-1 cells (MRP1)

Daunorubicin
Daunorubicin

↑ Accumulation
↑ Accumulation
↑ ATPase activity
↑

182
183

Glutathione
LT C 4 /E 2 17

GSH transport 146,184

146
32

↓ Transport

G

DNM
VBL
BCPCF
Calcein
Calcein

↓ Accumulation

↑ Accumulation

Human erythrocytes
MDCK-MRP1
MDCK-MRP2

↓ Efflux via MRP1

↓ Efflux
↔ Efflux

163
162

Chrysin Panc-1 cells (MRP1)

MDCK-MRP1
MDCK-MRP2

DNM/VBL
Calcein
Calcein

↑ Accumulation
↔ Efflux
↔ Efflux

32
162

Luteolin Panc-1 cells (MRP1) DNM

VBL
DNP-SG
Calcein
Calcein

↓ Accumulation
↔ Accumulation
↓ Efflux via MRP1
↓ Efflux
↔ Efflux

32

MCF7-pMTG5 cells
MDCK-MRP1
MDCK-MRP2

161
162

Diosmetin MDCK-MRP1

MDCK-MRP2

Calcein
Calcein

↓ Efflux
↔ Efflux

162

Diosmin Panc-1 cells (MRP1) DNM/VBL ↔ Accumulation 32

( Continued )