TOXICITY OF CARBON NANOTUBES - Carbon Nanotubes: From Bench Chemistry to Promising Biomedical Applications - page 224

5 Biological

interactions of
functionalised
single-wall carbon
nanotubes in
human epidermal
keratinocytes

International
Journal of
Toxicology ,
2007, 26 (2),
103-113

Puriied CNTs + AHA
(6-aminohexanoic acid)
in DMF. (covalent bond
formation)

Neonatal human
epidermal
keratinocytes

Signiicant decrease in
viability from 0.00005to
0.05mg/mL

Concentration range
used: 0.00000005-
0.05mg/mL

6 Chemical

modiication of
SWNT alters in
vitro cell-SWNT
interactions

Journal of
Biomedical
Research Part
A , 2005, 76 (3),
614-625

1. Pristine
2. Puriied
3. Functionalised
with glucosamine
(amide bond
formation between
glucosamine and
SWCNTs )

3T3 mouse
ibroblasts

1. AP NT: At the lowest tested
concentration, 55% cell
viability
2. Puriied and glucosamine
functionalised: Dose-
dependent decrease in
viability but less toxic than
AP-NTs

Concentration
range used:
0.001-1.0%
(wt/vol)

7 Cytotoxicity of

single-wall carbon
nanotubes on
human ibroblasts

Toxicology In
Vitro , 2006, 20 ,
1202-1212

Reined SWCNTs Reined

MWCNTs

Human dermis
ibroblasts

Reined SWCNTs exhibited
the most toxic effect (at 25
μg/mL)

Concentration
range used: 0.8-100
μg/mL

8 Impact of carbon

nanotube exposure,
dosage and
aggregation on
smooth muscle cells

Toxicology
Letters , 2007,
169 (1), 51-63

Puriied and acid
treated

Rat aortic smooth
muscle cells

Signiicant effect on cell
viability

Concentration range
used:
0.18-0.22 mg/mL

9 Effect of single wall

carbon nanotubes
on human HEK293
cells

Toxicology
Letters , 2005,
155 (1), 73-85

Not stated whether it is
pristine or puriied

Human embryo
kidney cells
(HEK293)

SWCNTs inhibit the
proliferation of HEK293 cells.

Concentration range
used: 0.78125-
200 μg/mL