Biomedical Engineering Reference
In-Depth Information
Table 8.1 Effect of CNTs at different concentrations in several cell lines
No.
Article title
Journal/date of
article
Type of carbon nanotubes
Cell line used
Viability
Concentration (if
applicable)
Single-walled
(SWCNTs)
Multi-walled
(MWCNTs)
1
In vitro toxicity
evaluation of single
walled carbon
nanotubes on
human A549 lung
cells
Toxicology in
Vitro , 2007,
21 (3), 438-448
Non-functionalised
Human A549 lung
cells
Low acute toxicity
Concentration range
used:
1.56-800μg/mL
2
Multi-walled carbon
nanotubes induce
T lymphocyte
apoptosis
Toxicology
Letters , 2006,
160 , 121-126
1. Oxidised
2. Pristine
Jurkat T-leukemia
cells
Oxidised:
Loss of >80%
400μg/mL
Pristine:
Loss of less than 50%
400 μg/mL
3
Cellular toxicity
of carbon based
nanomaterials
Nano Letters ,
2006, 6 , 1121-
1125
1. Pristine
2. Oxidised
Initial: Three
different human
lung-tumour cell
lines, H596, H446
and Calu-1.
Principal
experiment: H596
Pristine: Cell viability
decreased but less
pronounced than that of the
other CBN materials used in
experiment
0.02 μg/mL
Acid treated: Signiicant
increase in toxicity compared
to the pristine MWCNTs.
4
Functionalised
carbon nanotubes
are non-cytotoxic
and preserve the
functionality of
primary immune
cells
Nano Letters ,
2006, 6 , 1522-
1528
1.
1,3-dipolar
cycloaddition
reaction
1. Puriied B
2. T lymphocytes
3. Macrophages
(obtained from
the spleen,
lymph nodes,
and peritoneal
cavity of BALB/c
mice)
No signiicant toxicity for all
three cell lines
10 μg/mL
2.
Oxidation/
amidation
methodology
 
 
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