Biomedical Engineering Reference
In-Depth Information
Solvent emulsification-evaporation technique
Organic phase
Polymer and drug in
immiscible solvent
Aqueous phase
Stabilizer
Solvent displacement technique
Organic phase
Polymer and drug in
water miscible solvent
Aqueous phase
Stabilizer
Salting-out technique
Organic phase
Water addition
Polymer and drug in
water miscible solvent
Aqueous phase
Stabilizer and salting-
out agent
Emulsification-difussion technique
Organic phase
Water addition
Polymer and drug in
partir water miscible
solvent
Aqueous phase
Stabilizer
Double emulsion-evaporation technique
Organic phase
(W
1
/O)
(W
1
/O/W
2
)
Polymer a drug in
water immiscible
solvent, (emulsifier
optional)
Aqueous phase
(w1)
Emolsifier and drug
Aqueous phase
(w2)
Stabilizer
Spray-drying technique
Starting solution
Matrix former and drug
in water or organic
solvent solution
FIGURE 23.4
Methods used to prepare nanoparticles from preformed polymers.
