Chemistry Reference
In-Depth Information
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R-thalidomide
Although there have been many advances and discoveries, there remains a
need for new pharmaceuticals. Diseases such as cancer, aids, and Alzheimer's
claim many victims each year. Despite the long process from discovery to
market, the high costs associated with research and clinical trials, and the low
probability of success for each lead compound, there is reason to hope that
the pharmaceutical industry will make strides in these and other areas in the
years to come.
QUESTIONS
1.
A seven-step synthesis of a drug has each of reactions one through six
having a yield of 95.0% (i.e. 95.0% for reaction one, 95.0% for reaction
two, etc.) and reaction seven has a yield of 90.0%. What is the overall
yield (use three significant figures)?
2.
What is a typical length of time to bring a drug to market (discovery
through commercialization)?
a.
6 - 8 months
b.
2 years
c.
12 years
d.
22 years
3.
What are the odds of a compound in the discovery phase being commer-
cialized as a drug?
a.
about 1 in 2 (half) make it to commercialization
b.
about 1 in 5
c.
about 1 in 100
d.
about 1 in 250
e.
less than 1 in 10,000
4.
In developing the most effective cost position for a synthesis, three major
considerations are: (
(fill in consideration #3 using fewer than 10 words in
your answer)
1.
as few steps as possible
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