Pharmaceuticals - Fundamentals of Industrial Chemistry: Pharmaceuticals, Polymers, and Business - page 180

2. high yield reactions
3. __________________________________________________
5. For a racemic pharmaceutical, typically …

a. each enantiomer has the same bioactivity
b. one enantiomer has bioactivity and the other has less activity or is
inactive
c. one enantiomer has bioactivity and the other has the opposite effect
d. it is impossible to distinguish the bioactivity of the enantiomers

6. What does the c in cGMP stand for?
7. Drug regulations have been strengthened over the years because of vari-
ous tragedies. Which of the following events did not occur?
a. children were fed cough syrup with ethylene glycol solvent
b. a drug to alleviate nausea in pregnant women was used in Europe and
caused birth defects
c. people died after taking horsetail weed as a cure for diabetes
d. people died from the dye after drinking green beer colored with Green
No. 3 dye
e. a generic drug company falsified data submitted to the FDA

8. (True or False) Detailed SOPs must be followed to ensure product quality
and uniformity.

9. A drug entering phase I has about a ___% success rate; typically from the
first discovery it takes about _____ years and $_______ to bring a drug
to market.
a. 1% 2 years $50,000,000
b. 25% 2 years $200,000,000
c. 85% 12 years $1,200,000,000
d. 12% 12 years $100,000,000
e. 12% 12 years $1,200,000,000
10. What is the overall yield of a three-step synthesis that has a first reaction
having a yield of 70%, a second reaction having a yield of 80% and a
third reaction having a yield of 90%?
a. 80%
b. 70%
c. 60%
d. 50%