Biomedical Engineering Reference
In-Depth Information
Figure 5.4
(A)
1
H-
15
N HSQC spectra of the intrinsically disordered C-terminal
transactivation domain of hypoxia inducible factor-1a (HIF-1a) free
(black) and in complex with the TAZ1 domain of CBP (red.)
48
(B) One
member of an ensemble of structures of the complex between HIF-1a
(red) and TAZ1 (blue).
48
5.3.2 The NFkB-IkBa Interaction: a Fold/Unfold Symphony
The interactions of NFkB and its inhibitor IkBa provide an example of a
system where both folding and unfolding are used to tune the interaction in
response to the requirements of the cell. NFkB is a cellular transcription factor
that responds to external stimuli by the transcription of response genes. The
