From Bench to Beside to Cure Spinal Cord Injury: Lost in Translation? - International Review of Neurobiology - page 174

cont'd

Specific
treatment

Lesion
level

Route of
administration Treatment strategy Study Species Model Behavioral effects

NEP1 40 Steward, Sharp, Yee,

et al. (2008)

Mouse Dorsal

overhemisection

T6-7 Daily injections
(2 weeks), i.p.

Acute BBB 3

D þ

(7-14 days),

0 (17-22 days), foot
print and grid walk no
difference

sNgR Li, Liu, Budel, et al., (2004) Rat Dorsal

overhemisection

T6-7 Minipump (4 weeks),
intrathecal

D BBB þ 2 (14 days), þ 3
(28 days)

RhoA inactivation/
rho kinase inhibition

C3
Y27632

Dergham, Ellezam,
Essagian, et al. (2002)

Mouse Dorsal

overhemisection

T7 Direct injection into

lesion, fibrin adhesive
delivery system

C3 transferase þ Y-27632
D BBB þ 8 (24 h!), C3
transferase þ 6 (29 days),
Y-27632 þ 3 (29 days)

C3
Y27632

Fournier, Grandpre, and
Strittmatter (2001)

Rat 1/2 Dorsal

transection

T3-4 Minipump (4 weeks),
intrathecal

D BBB 5 (14 days),
0 (28 days)

BA-210 Lord-Fontaine, Yang, Diep,

et al. (2008)

Rat/
mouse

Contusion/dorsal
overhemisection

T9/T7 Direct injection into
lesion, fibrin adhesive
delivery system
(immediately, 24 h,
72 h)

Rat D BBB 0 (14 days)
þ

2 (42 days)
Mouse immediate BBB

D

4 (16 days),
Mouse 24 h delay

þ

BBB

D

3 (16 days)
Mouse 72 h delay

þ

BBB

D

0 (16 days)

Y-27632 Chan, Khodarahmi, Liu,

et al. (2005)

Rat Cervical dorsal

column transection

C4/5 Minipump (2 weeks),
intrathecal

Moderate improvement
in food pellet reaching,
foot print analysis,
horizontal ladder

p21 Cip1/WAF1
Y-27632
Fasudil

p21 Cip1/WAF1 , Y-27632,
Fasudil

Tanaka, Yamashita, Yachi,
et al. (2004)

Rat Dorsal hemisection T10 Minipump (2 weeks),

local BBB 2

D þ

(4-6 weeks)