Biology Reference
In-Depth Information
C3
Y-27632
Fasudil
Sung, Miao, Calvert, et al.
(2003)
Rat
Contusion
T9/10 C3 epidurally
Fasudil i.p.
Y-27632 p.o.
C3 no data due to severe
weight loss, Fasudil
D
3 (5 weeks),
Y-27632 immediately
D
BBB
þ
8 (10 days),
0 (42 days), Y-27632
delayed
0 (42 days)
BBB
Fasudil
Nishio, Koda, Kitajo, et al.
(2006)
Rat
Contusion
T9
Minipump (2 weeks),
local
Immediate
D
BBB
2
(12 weeks, not
significant), delayed
4 weeks post injury
D
BBB
0 (12 weeks)
Rat
Complete
transection
T8/9 Grafts at/caudal to
lesion site
D
BBB
þ
2to6
(19 weeks)
a
Immunomodulation
Stimulated
macrophages
Rapalino, Lazarov-Spiegler,
Agranov, et al. (1998)
Stimulated
macrophages
Bomstein, Marder, Vitner,
et al. (2003)
Rat
Contusion
T9
4-9 days delayed
grafts to caudal
border
8/14 grafted and 1/19
non-grafted rats BBB
6
in one hind limb
Remyelination
hESC-derived
oligodendrocyte
progenitor cells
Keirstead, Nistor, Bernal,
et al. (2005)
Rat
Contusion
T10
7 days delayed grafts
4 mm caudal
2 (19-45 days);
moderate improvement
in four-parameter
kinematic analysis
BBB
D
þ
rostral
þ
to
lesion
cyclosporine
þ
hESC-derived
oligodendrocyte
progenitor cells
Sharp, Frame, Siegenthaler,
et al. (2010)
Rat
Contusion
C5
7 days delayed grafts
1.2 mm
caudal
Moderate improvement
in foot print analysis
rostral to
þ
lesion
cyclosporine
þ
a
Animals with a BBB score
5 were considered as nonresponders.
