From Bench to Beside to Cure Spinal Cord Injury: Lost in Translation? - International Review of Neurobiology - page 173

Table 7.1 Preclinical studies on myelin-associated inhibitor neutralization, Rho-pathway inhibition, immunomodulation, and remyelination

Specific
treatment

Lesion
level

Route of
administration Treatment strategy Study Species Model Behavioral effects

Myelin-associated
inhibitor neutralization

IN-1 Schnell and Schwab (1990) Rat 2/3 Dorsal

transection

T5-7 Hybridoma
intracerebral

Not analyzed

IN-1 Bregman, Kunkel-Bagden,

Schnell, et al. (1995)

Rat Right

overhemisection

T6 Hybridoma

intracerebral

Moderate improvement
contact placing, foot
print analysis

IN-1 Merkler, Metz, Raineteau,

et al. (2001)

Rat Dorsal

overhemisection

T8 Hybridoma

intracerebral

2
(35 days); numerous tests
moderate improvement

BBB 2 (14 days)

D þ þ

IN-1 Fouad, Klusman, and

Schwab (2004)

Marmoset Hemisection T8 Hybridoma

intracerebral

Not analyzed

mAb 11C7
mAb 7B12

Liebscher, Schnell, Schnell,
et al. (2005)

Rat 1/2 Dorsal

transection

T8 Minipump (2 weeks),

intrathecal

2
(55 days); numerous tests
moderate improvement

BBB 2 (15 days)

D þ þ

mAb 7B12
mAb
h-Nogo-A

Freund, Schmidlin,
Wannier, et al. (2006)

Macaque Dorsolateral
transection

C7-8 Minipump (4 weeks),
intrathecal

Manual dexterity
improved; hindlimb
function unchanged

NEP1-40 Grandpre, Li, and

Strittmatter (2002)

Rat 1/2 Dorsal

transection

T6-7 Minipump (4 weeks),
intrathecal

D BBB þ 4 (14-30 days)

NEP1-40 Li and Strittmatter (2003) Mouse Dorsal

overhemisection

T6-7 Daily injections
(2 weeks), systemic

Acute D BBB
0 (10 days), þ 3
(17 days), Foot print and
grid walk moderate
improvement, 7 days
delayed D BBB
0 (14 days), þ 3
(28 days)