Biology Reference
In-Depth Information
Chitosan-
collagen tube
Blending
with collagen
-
Rats
Sciatic
nerve
Nerve
transection
-
Gait analysis and
behavioral test
Unblended
chitosan
nerve guide
12 weeks Collagen-blended
chitosan nerve guide
enhances motor and
sensory recovery
compared with
unblended nerve
guides
Patel et al.
(2008a,
2008b)
Chitosan film
Conjugation
with C(G)
YIGSR
peptide from
laminin-1
Chitosan
nonwoven
nano-/
microfibers
mesh
Male
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
transection
10
Static toe spread
factor (STSF) and
histological
evaluation
Autograft
10 weeks Nerve regeneration in
the chitosan/
CYIGSR group is
similar to the
autograft
Wang, Itoh,
Matsuda,
Aizawa,
et al. (2008)
and
Wang,
Itoh,
Matsuda,
Ichinose,
et al. (2008)
Thiolated and
nonthiolated
hydroxyapatite-
coated chitosan
tube
Adsorbed
YIGSR
peptide from
laminin-1
-
Male
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
transection
15
Electrophysiological
and histological
evaluation
Autograft
12 weeks YIGSR peptide
enhances nerve
regeneration and
axonal sprouting from
the proximal stump to
the distal one
Itoh et al.
(2005)
Circular and
triangular cross-
section chitosan
tube
Absorption
of laminin
and YIGSR
and IKVAV
laminin-
peptide
-
Male
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
transection
15
Electrophysiological
and histological
evaluation
Autograft
12 weeks Triangular tubes have
higher mechanical
strength and inner
volume than circular
ones. SC migration
and axonal outgrowth
is enhanced. Nerve
tissue regeneration
occurs in both
laminin and laminin-
peptide groups
Itoh,
Suzuki, et al.
(2003)
Continued
