Biology Reference
In-Depth Information
Table 1.6 Modifications to chitosan conduits surface used in peripheral nerve repair
Surface modification
Gap
size
(mm) Methods
Surface
modification
Follow-
up
Authors and
year
Nerve tube
Internal filler
Animal
Nerve
Injury
Controls
Outcome
Chitosan
nanofibers
mesh tube
Coating with
polarized and
nonpolarize-
b
-tricalcium
phosphate
particles
-
Male
Wistar
rats
Sciatic
nerve
Nerve
transection
10
Static toe spread
factor (STFS), von
Fray hair test,
electrophysiological
and histological
evaluation
Autograft
12 weeks Motor and sensory
nerve function and
electrophysiological
recovery progress
with time in each
group.
Immunofluorescence
reveals more rapid
nerve regeneration in
the polarized tube
group compared with
the nonpolarized tube
group. The axon
density and axon area
in the polarized tube
group are significantly
greater than those in
the chitosan mesh
tube and
nonpolarized group,
and it shows no
significant differences
from the control
group
Wang, Itoh,
et al. (2010)
and
Wang,
Wen, Lan,
and Li
(2010)
Chitosan-
collagen tube
Blending
with collagen
Longitudinally
oriented
microchannels
Rats
Sciatic
nerve
Nerve
transection
15
Functional and
histological
evaluation
Autograft
-
Chitosan-collagen
scaffolds achieve
nerve regeneration
and functional
recovery equivalent
to autograft.
Hu et al.
(2009)
