Biology Reference
In-Depth Information
Gap
size
(mm) Methods
Surface
modification
Follow-
up
Authors and
year
Nerve tube
Internal filler
Animal
Nerve
Injury
Controls
Outcome
Circular and
triangular cross-
section chitosan
tube coated
with
hydroxyapatite
Absorption
of laminin
and YIGSR
and IKVAV
laminin-
peptide
-
Male
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
transection
15
Electrophysiological
and histological
evaluation
Autograft
8 weeks Triangular tubes
coated with
hydroxyapatite have
higher mechanical
strength and inner
volume than circular
ones. Nerve tissue
regeneration occurs in
both laminin and
laminin-peptide
groups matching
isograft group.
Functional recovery is
delayed
Itoh,
Yamaguchi,
et al. (2003)
Triangular
cross-section
chitosan tube
Covalent
binding of
laminin and
YIGSR and
IKVAV
laminin-
peptide
-
Male
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
transection
15
Electrophysiological
and histological
evaluation
Autograft
8 weeks YIGSR, followed by
IKVAV, laminin-
peptide matches the
effectiveness of intact
laminin in enhancing
nerve regeneration
Suzuki et al.
(2003)
Chitosan-
collagen film
Blending
with collagen
-
Rats
Sciatic
nerve
Nerve
transection
5or
10
Electrophysiological
and histological
evaluation
Autograft
12 weeks
In 5-mm defects,
nerve regeneration is
similar to control
group. In 10-mm
defects, nerve
regeneration is
inferior to control
group. Chitosan-
collagen film conduits
are degraded at
12 weeks postsurgery
Wei et al.
(2003)
