The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System - International Review of Neurobiology - page 21

Chitosan-
alginate
tube

Bone
marrow
stromal
cells
(BMSCs)

Chitosan-alginate
freeze-dried sponge
scaffold

Female
Sprague-
Dawley
rats

Hemitransection at
the T9 level

- Basso-Beattie-

Bresnahan (BBB)
test, germ
agglutinin-
horseradish
peroxidase
retrograde tracing
and histological
evaluation

Direct
suture of
spinal dura
mater after
the lesion

6 weeks Chitosan-alginate
scaffolds
combination with
BMSCs result in
better functional
recovery and
axonal regrowth in
comparison with
control group

Wang
et al.
(2010) and
Wang,
Wen, Lan,
and Li
(2010)

Chitosan
tube

Neural
stem cells
(NSCs)

Multicellular sheets Rats Complete

transection model
of spinal cord injury

- Histological

evaluation

NSCs
transplanted
without
chitosan
channel

5 weeks In vivo survival of

NSCs and
differentiation into
astrocytes and
oligodendrocytes.
Host neurons were
identified in the
tissue bridge
formed within the
chitosan tubes

Zahir et al.
(2008)