Biology Reference
In-Depth Information
Table 1.3 Types of supportive cells used to enhance chitosan tubes in spinal cord repair
—
cont'd
Combination with cells
Gap
size
(mm) Methods
Nerve
tube
Follow-
up
Authors
and year
Cell type
Internal filler
Animal
Injury
Controls
Outcome
AMP (dbcAMP)
and NSPCs
facets of the
vertebrae at T7-T9
were also removed
Combination of
NSPCs with
chitosan tube
results in extensive
axonal
regeneration into
the injury site and
improvement of
functional recovery
Chitosan
tube
Neural
stem cells
(NSCs)
-
Female
Sprague-
Dawley
rats
Laminectomy at
T7-T9 and spinal
cord compression
at T8 with a 35-g
clip for 1 min
5
Basso-Beattie-
Bresnahan (BBB)
test and
histological
evaluation
NSCs
transplanted
without
chitosan
channel
6 weeks Chitosan channels
enhance the
survival of
transplanted NSCs.
There is no
difference in
functional recovery
between treatment
and control group
Bozkurt
et al.
(2010)
Chitosan
tube
Radial glial
cells
-
Female
Sprague-
Dawley
rats
Complete spinal
cord transection at
T8 level
3
Histological
evaluation
-
14 weeks After 14 weeks,
radial glial cells are
organized in
longitudinal cord.
Axons regenerate
across the chitosan
tube
Nomura
et al.
(2010)
