Biology Reference
In-Depth Information
Table 6.1 Major neurotrophic factors affected by physical exercise
—
cont'd
Role in
neuroprotection
and
neuroregeneration
Expression during
peripheral nerve
regeneration
Neurotrophic
factor
Pattern of
expression
Effect of physical
activity
Receptor
References
HGF
c-met
Survival of
subpopulations of
motoneurons
Possibly supports
activity-dependent
motoneuronal
survival
Yamamoto et al.
(1997)
IGF-1
IGFR-1 Survival and
neuroprotection
of motoneurons
Branching of
regenerating
motoneurons
IGF-1 is
overexpressed by
denervated
Schwann cells
Supports activity-
related
motoneuronal
survival (intact
nerve)
Deforges et al.
(2009)
IGF-1 required for
passive exercise-
induced functional
recovery after facial
nerve damage
Kiryakova et al.
(2010)
