Biology Reference
In-Depth Information
NT-4/5
trkB
(high
affinity)
p75 NTR
(low
affinity)
Survival of
motoneurons
Axonal sprouting
in adult intact
nerve
NMJ functional
plasticity
Preferential
recovery of slow
motor units
Preferential
production by
slow-type muscle
fibers
NT-4/5 muscle
expression declines
after nerve injury
NT-4/5 levels
increase with
electrical stimulation
NT-4/5 muscle
levels decline with
muscle denervation
Funakoshi et al.
(1995)
NT-4/5 muscle
levels increase with
muscle activity
Funakoshi et al.
(1995)
NT-4/5 muscle
levels do not change
with mechanical
compression, passive
stretching, or muscle
injury
Funakoshi et al.
(1995)
NT-4/5 expression
in proximal nerve
stumps is required
for the effect of
treadmill running in
enhancing axonal
growth
English, Meador,
and Carrasco (2005)
Expression of trkB
receptors is
upregulated by
exercise
Ghiani, Ying, Vellis,
and Gomez-Pinilla
(2007) , Wood et al.
(2011)
Continued
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