Biomedical Engineering Reference
In-Depth Information
Reagent-based approach
Distinct
molecular
skeletons
Common
starting material
Substrate-based approach
Common reagents
Distinct
molecular
skeletons
Different 'pre-encoded'
starting matrerials
FIGURE 1.4
Representation of the two general strategies for the creation of chemically and
skeletally diverse molecules.
scaffolds. The pair stage can generate diversity either by reagent-based pathways,
where different functional groups can be paired under orthogonal reaction condi-
tions, or by substrate-based pathways, where the same functional groups are paired
under common reaction conditions (Figure 1.5). In the latter case, the diversity gen-
erated in the pair stage is due to the relative positions of the functional groups that
are paired together. The build/couple/pair approach has subsequently been widely
adopted in the literature [43-45].
Important examples of DOS using these various strategies are discussed next.
