Biomedical Engineering Reference
In-Depth Information
(a)
Cou
p
le
Buil
d
Pai
r
(b)
Buil
d
Cou
p
le
Pair
Coupling functional group
Pairing functional group
FIGURE 1.5
Build/couple/pair strategy utilizing (a) reagent-based diversification and
(b) substrate-based diversification.
1.8 REAGENT-BASED APPROACHES TO DIVERSITY GENERATION
1.8.1 Use of Pluripotent Functional Groups
The use of pluripotent functionality in DOS can be neatly illustrated by two libraries.
These libraries were produced from small simple starting materials, which were then
subjected to a number of complexity-generating reactions to give a range of diverse
and structurally complex compounds in a small number of synthetic steps.
