Biomedical Engineering Reference
In-Depth Information
(a)
(b)
Figure 13.3.
AFMphaseimagesofnanofibrousscaffoldsurface;(a)PHBV
and (b) PHBV-Col(adapted from Ref. 16). See also Color Insert.
13.4.2
Electrospun PHBV/Gelatin Composite
Nanofibrous Scaffolds
Among natural biopolymers, gelatin can be obtained by denatur-
ing collagen and has almost an identical composition and biologi-
cal properties as those of the parent collagen. Much attention has
been focused on the use of gelatin as a tissue engineering material,
due to its low cost. To prepare a PHBV/gelatin composite scaffold,
a transparent polymer solution was prepared by dissolving gelatin
and PHBV in 2,2,2-trifluoroethanol (TFE) at a ratio of 50/50 with
su
cient stirring at room temperature. To examine the effect of
the gelatin content on fiber morphology, a 6 wt% polymer solution
was prepared, using different ratios of PHBV and gelatin. To exam-
ine the effect of the polymer concentration on fiber morphology, a
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