Fluorescent Macromolecular Sensors of Enzymatic Activity for In Vivo Imaging - Progress in Molecular Biology and Translational Science - page 363

Table 9.1 Enzyme-activated NIR-dye-labeled macromolecular imaging probes and their use for optical imaging in vivo—cont'd

Fluorophore,
mol/mol carrier
macromolecule Animal model

Macromolecule,
type

Target/background
ratio

Imaging
method

Specificity Reference

PGC Cathepsin K Cy5.5, 18 Murine atherosclerosis,

surgically exposed

1.7 IM 87

ProSense 680 Cathepsin

B/H/L/S

VivoTag 680 Colonic
adenocarcinomas

8.9 Microendoscopy 88

Noncovalently bound
homotetrameric
avidin

Lectin
receptor

Rhodamine X,
3

Murine peritoneal
ovarian metastases

IM 89

Galactosamine-
conjugated serum
albumin (GmSA)

D -galactose

Rhodamine X,
20

Murine peritoneal
ovarian metastases

IM 90

PGC; ProSense 750 Cathepsin
B/L/S

VivoTag 750 Murine pulmonary
inflammation

3 FMT 91

ProSense 680,
MMPSense680

Cathepsin
B/H/L/S
and MMP2/
3/9/13

VivoTag 680 Murine pancreatic
cancer

Allowed detection of
tumors 1-2 mm

PE and intravital
FCFM

92

PAMAM-4
dendrimer

MMP7 Cy5.5, 8 Murine intestinal

adenoma

2.2 in vivo
6 ex vivo

PE 93

þ peptide

PGC; ProSense 750 Cathepsin
B/L/S

VivoTag 750 Murine ovarian cancer
metastases to peritoneal
cavity

3.5 LP 94