Fluorescent Macromolecular Sensors of Enzymatic Activity for In Vivo Imaging - Progress in Molecular Biology and Translational Science - page 364

PGC; MMPSense MMP9 and

2; 3, 7-10;
and 12-16

Cy5.5 Murine stroke 1.3 PE 95

ProSense 680 Cathepsin

B/H/L/S

VivoTag 680 Rodent pancreatic
cancer

Detection rate with 100%
sensitivity and 92.2%
specificity

Intravital
FCFM

96

Peptides (PS-5,
PS-25, PS-40)

Cathepsin B VivoTag 680 Murine atherosclerosis PS5 ex vivo ¼ 4.76, PS40 ex FRI and

FMT

97

vivo ¼ 7.13, PS40

in vivo 2.75

ProSense 750 MMP 2/3/

7/9/12/13

VivoTag 750 Murine esophageal
adenocarcinoma

4.5 FEN 98

PGC-800 Cathepsin

B/H/L/S

IRDye
800CW

Murine myocardial
infarction

FLI 45

a Calculated using data from the original reports referenced in this table.
b PGC, protected graft copolymer, that is, MPEG-bPLL.
c PE, planar excitation; FRI, fluorescence reflectance imaging; FMT, fluorescence molecular tomography; LP, laparoscopy; IM, intravital microscopy; FCFM, fiberoptic
confocal fluorescence microscopy; PAMAM, PEGylated polyamidoamine; FEN, fluorescence endoscopy; FLI, Fluorescence lifetime imaging.
d Commercially available probes based on PGC (ProSense TM , MMPSense TM , and Angiosense TM , Perkin-Elmer, Waltham MA).