Fluorescent Macromolecular Sensors of Enzymatic Activity for In Vivo Imaging - Progress in Molecular Biology and Translational Science - page 362

PGC Cathepsin

B/H/L/S

Cy5.5 Murine lymph

node metastasis

4.8 (i.v. injection)
6.6 (SC injection)

FRI 76

PGC HIV-1PR Cy5.5 Murine glioma as

abdominal xenograft

4 PE 77

PGC Cathepsin

B/H/L/S

Cy5.5 Murine osteoarthritis 50-70% signal

reduction post therapy

FRI 78

PGC Caspase-1 Cy5.5, 18 Murine glioblastome-

expressing caspase-1

1.7 PE 79

PGC Cathepsin

B/H/L/S

Cy5.5 Murine osteoarthritis 3 FRI 80

PGC MMP2 Cy5.5 Murine glioma Twofold FMT signal

decrease after MMP3
inhibition

FMT 81

PGC MMP2

and 9

Cy5.5 Murine myocardial

infarction ex vivo

7 IM 82

ProSense 680 d Cathepsin

B/H/L/S

VivoTag 680 Murine lung carcinoma FMT 83

PGC uPA Cy5.5 or Cy7,

15-19

Murine fibrosarcoma
and adenocarcinoma

3.2 and 3.1 FRI 84

PGC MMP2

and 9

Cy5.5 Murine atherosclerosis

(ApoE ko)

5( ex vivo ) FRI, FMT 85

ProSense 680 Cathepsin

B/H/L/S

VivoTag 680,
6

Murine myocardial
infarction

19 FMT 86