Mechanisms and Dynamics of Heterochromatin Formation During Mammalian Development: Closed Paths and Open Questions - Current Topics in Developmental Biology - page 11

Suv39H1/2 SET Catalyzes

H3K9me3

Centromeric,
pericentromeric,
and telomeric
heterochromatin

Embryo
(full KO)

Prenatal lethality Peters et al.

(2001)

Chromo Recognizes

methylated
lysines (e.g.,
H3K9me3)

Replacement of
H3K9me3 in
heterochromatin with
H3K27me3

Germ line
(conditional
KO)

Infertile male mice

Increased defects
following DNA damage
and missegregation
during meiosis

Puschendorf et al.
(2008)

HP1 a Chromo Recognizes

methylated
sites
(H3K9me3)

Heterochromatin Embryo
(full KO)

No developmental
phenotype reported

Aucott et al.
(2008)

Chromoshadow Protein-
protein
interactions

Brown et al.
(2010)

Hinge RNA/DNA

interactions

Continued