Mechanisms and Dynamics of Heterochromatin Formation During Mammalian Development: Closed Paths and Open Questions - Current Topics in Developmental Biology - page 10

maintenance—cont'd
Methyltransferase Domain(s) Function(s) Location Knockout Phenotype References

GLP SET Catalyzes

H3K9me3

Euchromatin Embryo

(full KO)

Lethal between 9.5 and
12.5 dpc. Developmental
abnormalities

Tachibana et al.
(2005)

Catalyzes
H3K27me
in virto

Reduction not only in
H3K9me3 but also in
H3K9me1 andH3K9me2

ANK repeats Binds to

H3K9me1
and
H3K9me2

Mislocalization of HP1

Suv39H1 SET Catalyzes

H3K9me3

Centromeric,
pericentromeric,
and telomeric
heterochromatin

Embryo
(full KO)

No developmental effect Peters et al.
(2001)

Chromo Recognizes

methylated
lysines
(H3K9me3)

Suv39H1 SET Catalyzes

H3K9me3

Centromeric,
pericentromeric,
and telomeric
heterochromatin

Embryo
(full KO)

No developmental effect Peters et al.
(2001)

Chromo Recognizes

methylated
sites
(H3K9me3)