Mechanisms and Dynamics of Heterochromatin Formation During Mammalian Development: Closed Paths and Open Questions - Current Topics in Developmental Biology - page 12

Table 1.1 Embryonic phenotypes of the knock-outs of proteins and complexes involved in heterochromatin establishment and/or
maintenance—cont'd
Methyltransferase Domain(s) Function(s) Location Knockout Phenotype References

HP1 b Chromo Recognizes

methylated
lysines
(H3K9me3)

Heterochromatin Embryo
(full KO)

Perinatal lethality Aucott et al.

(2008)

Chromoshadow Protein-
protein
interactions

Aberrant cerebral cortex
development

Hinge RNA/DNA

interactions

HP1 g Chromo Recognize

methylated
lysines
(H3K9me3)

Euchromatin Embryo

(full KO)

Developmental effect? Takada et al.

(2011)

Chromoshadow Protein-
protein
interactions

Sterility of male mice Brown et al.

(2010)

Hinge RNA/DNA

interactions

Naruse et al.
(2007)

Suv4-20H1 SET Catalyzes

H4K20me2/
3

Heterochromatin Embryo
(full KO)

No developmental
phenotype reported

Schotta et al.
(2008)

Suv4-20H2 SET Catalyzes

H4K20me2/
3

Heterochromatin Embryo
(full KO)

No developmental
phenotype reported

Schotta et al.
(2008)