Biology Reference
In-Depth Information
Genes/pathways
(upregulated, downregulated)
Tissue/species
Stages, conditions
No. of genes
Platform
References
of T3 (e.g., Mad2, frizzled 7,
caspase-9, nuclear factor I-C1,
vitellogenin receptor,
natriuretic peptide receptor
type C), genes whose T3
repression was inhibited by
acetochlor (e.g., 51-kDa
cytokeratin type I,
Genes 17, 18, 19, glutamine
synthetase, Gli2)
Intestine/
X. laevis
NF53, 10 nM T3,
0, 1, 3, 6 days
Up—255, 710,
1040; down—280,
552, 585
Early genes—proteolysis,
cell
cycle
; late genes—transcription,
development, ECM,
glucose
metabolism
,
transport
,
digestion
,
mitochondrion
Agilent oligoarray,
21,495 Unigene
clusters
Buchholz
et al. (2007)
Intestine/
X. laevis
NF53, 58, 61, 66
Up—463, 2613,
981; down—280,
552, 585
In chronological order:
immune response,
catabolism
;
transcription, signal
transduction, cell-cell
signaling,
metabolic processes
,
mitochondrion
; organismal
process, development,
catalytic
activity
,
RNA processing
Agilent oligoarray,
21,495 Unigene
clusters
Heimeier
et al., (2010)
Intestine/
X. laevis
NF54, 2 nM T3,
10
m
M BPA,
T3
T3—1051 up,
728 down; BPA—
507 up, 290 down;
T
Attenuated regulation of 58%
of genes regulated by T3 occurs
in the presence of BPA and
57% of the top 100 T3-
Agilent oligoarray,
21,495 Unigene
clusters
Heimeier
et al. (2009)
þ
BPA, 4 days
