Developmental Programs and Endocrine Disruption in Frog Metamorphosis: The Perspective from Microarray Analysis - Current Topics in Developmental Biology - page 330

Hind limb/
X. laevis

NF54, 100 nM T3,
0, 1, 2 days

2400 up,
1200 down

Cell cycle, MCM genes,
RNA/DNA metabolism,
electron transport

Agilent oligoarray,
21,654 elements

Das et al.
(2006)

Hind limb/
X. laevis

Dox-inducible
pCAR:TRDN c

2 weeks—42 up, 67
down; 6 weeks—
1401 up, 1915
down

Nonmuscle genes unchanged,
calsequestrin involved in
transgenic muscle-wasting
phenotype

Agilent oligoarray,
21,654 Unigene
clusters

Cai et al.
(2007)

MAGEX cDNA b ,
434 cDNAs

Hind limb/
X. laevis

NF54, 0, 1, 4 days,
T3 d , T4, MMI,
PTU, PER

10-14 across
treatments, time
points

RNA helicase II/Gu as
biomarkers for T4,
metallothionein as biomarker
for MMI, importin as
biomarker for MMI and PER

Helbing et al.
(2007)

Brain/
X. laevis

NF54, 100 nM T3,
0, 1, 2 days

2000 up, 1000
down

Cell cycle, MCM genes,
RNA/DNA metabolism,
electron transport, Notch,
Otx2

Agilent oligoarray,
21,654 Unigene
clusters

Das et al.
(2006)

MAGEX cDNA b ,
434 cDNAs

Brain/ X. laevis NF54, 0, 1, 2,

4 days, T3 d , T4,
MMI, PTU, PER

9-66 across
treatments, time
points

T3 versus T4 shows different
expression profiles; MMI,
PTU, PER-altered gene
regulation by 24 h; cyclin H as
biomarker for 24 h T3,
ferrochelatase as biomarker for
48 h T4

Helbing et al.
(2007)

Continued