Biology Reference
In-Depth Information
0, 1, 2 days
1500 up,
700 down
Intracellular signaling,
hydrolase activity, peptidase
activity, cell death,
energy
pathways
,
glycolysis
,
TCA cycle
,
mitochondrion
,
electron transport
21,654 Unigene
clusters
(2006)
MAGEX cDNA
b
,
434 cDNAs
Tail/
X. laevis
NF54, 0, 2 days,
T3
d
, T4, MMI,
PTU, PER
1-11 across
treatments,
time points
Metallothionein as biomarker
for MMI
Helbing et al.
(2007)
Tail/
X. laevis
NF54, 20 nM T3,
6, 48 h
6 h-177 up,
125 down;
48 h—432
up, 421 down
Genes at 6- and 48-h time
points mostly not overlapping,
enriched GO categories in
metabolic processes; TR
b
,
deiodinase II, CRH-binding
protein, fibroblast-activating
protein
a
as biomarkers for TH
Affymetrix, 14,400
elements
Searcy et al.
(2012)
Tail/
X. tropicalis
NF54, 10 nM T3,
100 nM CORT,
CORT
TH only—1636,
cort only—573,
CORTTH
only—1208
TH only: proteases, apoptosis,
transport,
amino acid metabolism
,
CORT only: mitochondrion,
intracellular localization and
transport, CORTTH only:
protein localization and
transport
Affymetrix, 59,000
elements
Kulkarni and
Buchholz
(2012)
þ
T3, 18 h
Tail/
X. laevis
NF52/54, 100 nM
T3, 10 nM
acetochlor,
T3
26 genes in T3
versus T3
T3-induced genes further
increased by acetochlor
(e.g., gene 12, TH/bZIP,
collagenase 3, KLF9,
deiodinase III), non-T3-
response genes induced by
acetochlor only in the presence
MAGEX cDNA,
420 cDNAs
Crump et al.
(2002)
þ
AC
þ
AC, 48 h
