Biomedical Engineering Reference
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FIGURE 3.8: Simulated multicellular spheroid transmesothelial migration
at 0, 2000, 4000, 6000, 7500, 9000, 10500, 12000 MCS. The tumor mass ad-
heres to the layer (B), and the subsequent expression of MMPs degrades the
ECM components and breaks the junctions between the mesothelial cells (C)
and (D). The disseminated spheroid invades the virtual mesothelium through
different foci of adhesion, causing the apoptosis of the mesothelial cells nearby
(E), (F), and (G). At the end of the simulation (H), the cancer mass has over-
taken a large area of the monolayer and starts the metastatic outgrowth.
Table C.4, and the fact that we also take into account the sedimentation of
the spheroid due to gravity, which directs, along with the classical chemotactic
cues, the motion of the tumor mass toward the layer. We use lower A
surface
C
and A
perimeter
C
C
and
perimete
C
since the tumor cells, ac-
quiring a spheroid morphology, are tightly packed and resistant to change
their shape, thereby remaining almost round with a constant volume/surface
ratio.
The strong homotypic interactions, regulated by the expression of E-
and higher
surface
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