Biomedical Engineering Reference
In-Depth Information
FIGURE 3.7: Summary of the simulations of single cell transmesothelial mi-
gration run with different parameters. All the other parameters not explicitly
cited are the same as in Table C.3 given in Appendix C.
cells. This situation is biologically plausible, since ovarian carcinoma individ-
uals are in origin epithelial-type cells, and therefore able to express the same
cell adhesion molecules as the mesothelial cells. In this case, tumor cell forms
close junctions with the layer, becoming part of it and losing its invasive ca-
pability. In contrast, for high values of J
C;M
(i.e., J
C;M
J
C;E
;J
M;M
), the
tumor cell has few adhesion points with the virtual mesothelium and therefore
it has not been able to activate the downstream cadherin-signals needed for
the transmigration program.
3.4 Multicellular Spheroid Invasion
The initial conditions of the simulation of the spheroid invasion are the same
as in Figure 3.5, but the tumor mass is formed by 10 virtual cells. The features
of the model are structurally analogous to those of the previous section and
the simulations last 12000 MCS ( 2 days), which allows one to neglect cancer
cell proliferation. The only differences are the parameters explicitly cited in
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