Biomedical Engineering Reference
In-Depth Information
TABLE C.9: Early Stages of Tumor Spheroid Growth. () indicates param-
eters that vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
volume
C
3380 [m
3
]
Cell volume
[50]
A
surface
C
1130 [m
2
]
Cell surface
[50]
T
0
Basal cell motility
4.5 [356]
h
Michaelis{Menten constant for T
1/3
[356]
volume
C
Cell compressibility
10
[356]
k
Rate of cell loose volume
1/5
[356]
surface
C
Cell stiffness
5
[356]
J
C;C
Cell{cell adhesive strength
2.5*
[356]
J
C;M
Cell{matrix adhesive strength
5
[356]
5 [M
1
]
Haptotaxis strength
[356]
10
3
[m
2
s
1
]
D
n
Diffusion constant of nutrients
[139]
n
On-rate constant of nutrient decay
2 10
4
[s
1
]
[138, 139]
1 [h
1
]
n
On-rate constant of nutrient uptake
[138, 139]
0.78 [h
1
]
n
On-rate constant of growth factor
production
[138, 139]
n
max
Maximal growth factor consumption
0.08
[pg/cell/h]
[140]
n
ext;0
Initial extracellular level of growth
factors
0.4 [M]
[356]
n
0
Basal intracellular level of growth
factors
0.5 [M]
[29,
67,
138]
n
l
Threshold level for necrotic transi-
tion
0.2 [M]
[29,
67,
138]
3 [h
1
]
p
On-rate constant of ECM protein
degradation
[286]
p
ext;0
Initial extracellular level of ECM
protein
4 [M]
[356]
5
4
[m
2
s
1
]
D
m
Diffusion constant of MMPs
[286]
2 10
3
[s
1
]
m
On-rate constant of MMP decay
[286]
5 10
3
[s
1
]
m
On-rate constant of MMP produc-
tion
[286]
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