Biomedical Engineering Reference
In-Depth Information
TABLE C.8: Dierent Morphologies of Tumor Invasion Fronts. () indicates
parameters that vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
surface
;N
50 [m
2
]
Surface of cell nucleus
[49]
A
perimeter
;N
Perimeter of cell nucleus
43 [m]
[49]
A
surface
;C
150 [m
2
]
Surface of cell cytosol
[49]
A
perimeter
;C
Perimeter of cell cytosol
90 [m]
[49]
T
;N
Generalized motility of the nucleus
1
[355]
T
0
Basal cell motility
4.5
[355]
h
Michaelis{Menten constant for T
1/3 [355]
surface
;N;C
Cell compressibility
10
[355]
perimeter
;C
Stiffness of cell cytosol
5*
[355]
perimeter
;N
Stiffness of cell nucleus
10
[355]
J
int
N;C
Generalized adhesion between nu-
cleus and cytosol
-20
[355]
J
ext
T;T
Cell{cell adhesive strength
5*
[355]
J
ext
T;M
Cell{matrix adhesive strength
2*
[355]
hapt
5* [M
1
]
Haptotaxis strength
[355]
10
3
[m
2
s
1
]
D
n
Diffusion constant of nutrients
[139]
2 10
4
[s
1
]
n
On-rate constant of nutrient decay
[138, 139]
1 [h
1
]
n
On-rate constant of nutrient uptake
[138, 139]
0.78 [h
1
]
n
On-rate constant of growth factor
production
[138, 139]
n
max
Maximal growth factor consumption
0.08
[pg/cell/h]
[140]
n
ext;0
Initial extracellular level of growth
factors
10 [M]
[355]
n
0
Basal intracellular level of growth
factors
0.2 [M]
[67, 138]
1.310
4
[s
1
]
p
On-rate constant of ECM protein
decay
[286]
3* [h
1
]
p
On-rate constant of ECM protein
degradation
[355]
p
ext;0
Initial extracellular level of ECM
protein
4 [M]
[355]
5
4
[m
2
s
1
]
D
m
Diffusion constant of MMPs
[286]
2 10
3
[s
1
]
m
On-rate constant of MMP decay
[286]
5 10
3
[s
1
]
m
On-rate constant of MMP produc-
tion
[286]
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