Biomedical Engineering Reference
In-Depth Information
TABLE C.6: (Continued.)
Parameter
Description
Value
Reference
K
n
Michaelis{Menten
constant
for
1 [M]
[351, 354]
VEGF-induced NO release
1.5* [Ms
1
]
v
ca
Maximal rate of NO release
[37, 274]
c
n
Dissociation constant between Ca
and eNOS
0.3 [M]
[312]
a
a
Dissociation constant between AA
and eNOS
0.2 [M]
[283]
c
0
Basal intracellular calcium concen-
tration
0.05 [M]
[33, 283]
D
c
Diffusion constant of Ca
220*
[m
2
s
1
]
[132,
212,
283]
24.7 [Ms
1
]
k
Ca
Maximal rate of calcium eux
[283, 399]
Ca
out
Limit for calcium extrusion
0.32 [M]
[283, 399]
6 [s
1
]
F
AA;max
Maximal rate of AA-induced cal-
cium influx
[274, 283]
4.5 [s
1
]
F
NO;max
Maximal rate of NO-induced cal-
cium influx
[274, 283]
q
a
Michaelis{Menten constant for AA-
activated channels
2 [M]
[274, 283]
q
n
Michaelis{Menten constant for NO-
activated channels
5 [M]
[274, 283]
300 [s
1
]
K
off
Dissociation
constant
between
[24]
buers and Ca
c
K
on
On-rate constant of Ca
c
buffering
100
[M
1
s
1
]
[24]
b
T
Total buffer concentration
450 [M]
[132, 283]
c
ext;0
Extracellular calcium level
2000 [M]
[33, 283]
TABLE C.7: Tumor-Derived Tubulogenesis. () indicates parameters that
vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
surface
;N
130 [m
2
]
Surface of cell nucleus
[133]
A
perimeter
;N
Perimeter of cell nucleus
35 [m]
[133]
A
surface
;C
1150 [m
2
]
Surface of cell cytosol
[133]
A
perimeter
;C
Perimeter of cell cytosol
150 [m]
[133]
5 [m
1
]
J
0
Basal adhesion strength
[135]
Coecient for J
ext
E;E
p
1/2
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