Biomedical Engineering Reference
In-Depth Information
TABLE C.6: Effect of Calcium-Related Pathways on Single Cell Motility.
() indicates parameters that vary in the dierent sets of simulations.
Parameter
Description
Value
Reference
A volume
;N
900 [m 3 ]
Volume of cell nucleus
[390]
A surface
;N
314 [m 2 ]
Surface of cell nucleus
[390]
A volume
;C
32000 [m 2 ]
Volume of cell cytosol
[390]
A surface
;C
1110 [m 2 ]
Surface of cell cytosol
[390]
volume
;N;C
Cell compressibility
20
[351, 354]
surface
;N
Stiffness of cell nucleus
20
[351, 354]
surf
0
Intrinsic stiffness of cell cytosol
12
[351, 354]
k
Michaelis{Menten
constant
for
1
[351, 354]
surface
;C
T 0
Basal cell motility
3.5
[309]
T ;N
Generalized motility of the nucleus
0.25
[351, 354]
h
Michaelis{Menten constant for T
1/2
[351, 354]
J int
N;C
Generalized adhesion between sub-
cellular units
-20
[351, 354]
c 0
basal chemotactic strength
0.2 [M 1 ]
[351, 354]
j
Michaelis{Menten constant for for
ch ;C
1/2
[351, 354]
pers
0
Basal inertia strength
0.8
[309]
10 [m 2 s 1 ]
D v
Diffusion constant of VEGF
[360]
1.8 10 4
[s 1 ]
v
On-rate constant of VEGF degrada-
tion
[360]
v
On-rate constant of VEGF secretion
0.78 [h 1 ]
[351, 360]
1 [h 1 ]
z
Coecient of the amount of bound
VEGF
[351, 354]
10 [m 2 s 1 ]
D a
Diffusion constant of AA
[283]
30 [s 1 ]
a
On-rate constant of AA degradation
[283]
30* [Ms 1 ]
k a
Maximal rate of VEGF-dependent
AA release
[283]
K a
Michaelis{Menten
constant
for
1 [M]
[283]
VEGF-induced AA release
v c
Maximal rate of Ca-dependent AA
release
0.75*
[Ms 1 ]
[351, 354]
c a
Michaelis{Menten constant for for
Ca-induced NO release
0.3 [M]
[351, 354]
D n
Diffusion constant of NO
3300
[m 2 s 1 ]
[226, 283]
0.1 [s 1 ]
n
On-rate constant of NO degradation
[283]
30* [Ms 1 ]
k n
Maximal rate of VEGF-induced NO
release
[351, 354]
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