Biomedical Engineering Reference
In-Depth Information
TABLE C.10: Cell Migration in Matrix Environments. () indicates param-
eters that vary in the different sets of simulations.
Parameter
Description
Value
Reference
A
surface
;N
34.7 [m
2
]
Surface of cell nucleus in 2D
[7]
A
perimeter
;N
Perimeter of cell nucleus in 2D
20.8 [m]
[7]
A
surface
;C
Surface of cell cytosol in 2D
104.3 [m
2
]
[7]
A
perimeter
;C
Perimeter of cell cytosol in 2D
62.6 [m]
[7]
A
volume
;N
155.2 [m
3
]
Volume of cell nucleus in 3D
[7]
A
surface
;N
138.8 [m
2
]
Surface of cell nucleus in 3D
[7]
A
volume
;C
1076.3 [m
3
]
Volume of cell cytosol in 3D
[7]
A
surface
;C
694.6 [m
2
]
Surface of cell cytosol in 3D
[7]
A
surface
F
20 [m
2
]
Surface of matrix fibers
[7]
A
perimeter
F
Length of matrix fibers
20 [m]
[162]
T
;N
Motility of cell nucleus
0.5
[353]
T
;C
Motility of cell cytosol
9
[353]
T
F
Motility of matrix fibers
0
[353]
volume
;N;C
Cell compressibility in 3D
10
[353]
surface
;N;C
Cell compressibility in 2D
10
[353]
surface
;N
Stiffness of cell nucleus in 3D
8.5*
[353]
perimeter
;N
Stiffness of cell nucleus in 2D
8.5*
[353]
surface
;C
Stiffness of cell cytosol in 3D
0.8
[353]
perimeter
;C
Stiffness of cell cytosol in 2D
0.8
[353]
surface
F
Compressibility of matrix fibers
11*
[353]
perimeter
F
Stiffness of matrix fibers
11
[353]
J
int
N;C
Generalized adhesion between nu-
cleus and cytosol
-20
[353]
J
ext
E;E
Cell{cell adhesive strength
12
[353]
J
ext
E;M
Cell{medium adhesive strength
6.5
[353]
J
ext
E;F
Cell{ber adhesive strength
4.5*
[353]
5
4
[m
2
s
1
]
D
m
Diffusion constant of MMPs
[286]
2 10
3
[s
1
]
m
On-rate constant of MMP decay
[286]
m
On-rate constant of MMP produc-
tion
5 10
3
[s
1
]
[286]
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