Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 34

Table 3.1 ( Continued )

Zebrafish Mammalian models

LC 50 /log
LC 50 (mg/L)

Compound

Target organs LD 50 /log LD 50 (mg/kg) Target organs

Diphenhydramine 89.3/1.95 Liver, kidney, teratogenic 500/2.69 (rat, oral), 35/1.54 (rat,

i.v.), 114/2.06 (mouse, oral),
20/1.30 (mouse, i.v.), 56/1.75
(mouse, i.p.)

Carcinogenic, teratogenic

Terfenadine 7.1/0.85 Heart, liver 5/0.70 (rat, p.o.), 2000/3.3

(mouse, oral)

Heart

Famotidine > 674/2.83 Gastrointestinal, heart > 3000/3.48 (rat, p.o.) No obvious toxicity

Cimetidine > 504/2.70 Heart, liver, gastrointestinal 5000/3.70 (rat, p.o.) Genome toxic, liver,

developmental toxic

Hydroxyzine 67.2/1.83 Gastrointestinal, heart 950/2.98 (rat, oral) Oral clefts, orofacial defects,

micromelia

Pyrilamine 51.3/1.71 Heart, liver 36/1.56 (rat, oral), 102/2.0

(mouse, i.p.)

Liver

Promethazine HCl 16.1/1.21 Heart, liver, gastrointestinal 15/1.17 (rat, i.v.), 50/1.70 (mouse,

i.v.), 255/2.41 (mouse, oral),
170/2.23 (rat, oral), 160/2.20
(mouse, i.p.)

Liver

Ranitidine Heart 60/1.78 (mouse, i.v.), 6610/3.82

(rat, oral)

Heart, liver

Nizatidine Heart Heart, liver

Enalapril 295.8/2.47 Heart, liver, craniofacial 2000/3.3 (rat, p.o.) Developmental toxic

Captopril 499.5/2.7 Heart, liver, craniofacial 4266/3.36 (rat, p.o.), 1000/3.0

(mouse, i.v.)

Developmental toxic