Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 35

Isoproterenol

> 495.4/2.69

Heart, liver necrosis,
gastrointestinal

800/2.90 (rat, p.o.) Cardiovascular

Epinephrine 266.4/2.43 Heart, gastrointestinal 24/1.38 (rat, p.o.), 4/0.6

(mouse, i.p.)

Cardiovascular

Salbutamol

> 478/2.68

Heart 660/2.82 (rat, oral) Smooth muscle

Terbutaline

> 548/2.74

Liver, heart,
gastrointestinal, pancreas

> 5000/3.70 (rat, p.o.)

Lidocaine 70.2/1.85 Heart 317/2.50 (rat, p.o.), 25/1.4

(rat, i.v.), 133/2.12 (rat, i.p.),
292/2.47 (mouse, oral),
19.5/1.29 (mouse, i.v.),
105/2.02 (mouse, i.p.)

Cardiovascular, CNS

Verapamil 147.3/2.17 Heart, liver, gastrointestinal 108/2.03 (rat, p.o.) Cardiovascular

Nifedipine 346/2.54 Liver, heart 1022/3.01 (rat, oral), 6/0.78 (rat,

i.v.), 230/2.36 (rat, i.p.), 202/2.31
(mouse, oral), 4200/3.62 (mouse,
i.v.), 185/2.27 (mouse, i.p.)

Cardiovascular

Digoxin 11.7/1.07 Heart, liver, gastrointestinal 28.27/1.45 (rat, oral), 25/1.4 (rat,

i.v.), 4/0.6 (rat, i.p.), 415/2.62
(mouse, oral), 7.4/0.89 (mouse,
i.v.), 40.6 (mouse, i.p.)

Heart, gastrointestinal

Quinidine 364/2.56 Brain, yolk, heart 263/2.42 (rat, oral), 23/1.36

(rat, i.v.), 140/2.15 (rat, i.p.),
173/2.24 (mouse, i.p.)

Heart

Procainamide 544/2.74 95/1.989 (rat, i.v.), 312/2.49

(mouse, oral), 103/2.01
(mouse, i.v.)

Clonidine 9.3/0.97 Heart 157/2.20 (rat, oral), 108/2.03

(mouse, oral)

Cardiovascular, CNS, eye

( continued )