Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 33

Chlorpromazine 107/2.02 Heart, jaw, brain 225/2.35 (rat, oral) Reproductive, dermal

Fluoxetine 13.8/1.14 Liver, heart,

gastrointestinal

452/2.66 (rat, oral), 248/2.39
(mouse, oral)

Liver, kidney

Thiothixene 38.4/1.58 Liver, pancreas 720/2.86(rat, oral), 400/2.60

(mouse, oral)

Heart

Naproxen 13.2/1.12 Liver, gastrointestinal 435/2.63 (mouse, i.v.), 534/2.73

(rat, oral), 1234/3.09 (mouse,
oral)

Gastrointestinal

Ibuprofen 5.56/0.74 Liver, kidney 495/2.69 (mouse, i.p.), 636/2.80

(rat, oral), 626/2.80 (rat, i.p.),
740/2.87 (mouse, oral)

Kidney

Aspirin 100.9/2.0 Gastrointestinal,

teratogenic, kidney,
muscle

167/2.22 (mouse, i.p.), 1500/3.18
(rat, oral), 1100/3.04 (mouse,
oral)

Gastrointestinal, kidney, ureter,
cardiovascular, muscle

Acetaminophen 252/2.4 Liver 500/2.69 (mouse, i.p.), 1944/3.29

(rat, oral)

Liver, kidney, gastrointestinal

Indomethacin 3.58/0.55 Liver, gastrointestinal,

kidney

12/1.08 (rat, oral), 50/1.70
(mouse, oral)

Liver, gastrointestinal, kidney

Colchicine 120/2.08 Liver, gastrointestinal 6.1/0.78 (rat, i.p.), 1.6/0.20

(mouse, i.v.), 5.9/0.77
(mouse, oral)

Mutagenic, teratogenic,
gastrointestinal, bone marrow
depression

Diclofenac 1.6/0.20 Developmental, liver,

gastrointestinal

Not available Liver, gastrointestinal

Cyclosporin A 69/1.83 Teratogenic, liver,

cardiovascular, kidney

170/2.23 (mouse, i.v.), 1489/3.17
(rat, oral), 147/2.17 (rat, i.v.),
24/1.38 (rat, i.p.), 2803/3.45
(mouse, oral)

Kidney, ureter, bladder

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