Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 32

Table 3.1 ( Continued )

Zebrafish Mammalian models

LC 50 /log
LC 50 (mg/L)

Compound

Target organs LD 50 /log LD 50 (mg/kg) Target organs

Barbituric acid 166.4/2.22 Heart, eye, liver 900/2.95 (rat, oral) CNS

Buspirone 126.6/2.1 Liver, gastrointestinal, CNS 196/2.29 (rat, oral), 655/2.82

(mouse, oral)

CNS, heart, gastrointestinal

Clozapine 11.45/1.06 Heart, gastrointestinal, liver 251/2.4 (rat, oral), 58/1.76

(rat, i.v.), 199/2.3 (mouse,
oral), 58/1.76 (mouse, i.v.)

Heart, CNS

Thioridazine 10/1 Liver, heart, brain, yolk 1060/3.03 (rat, oral) CNS

Imipramine 24/1.38 Liver, gastrointestinal,

heart, swim bladder

305/2.48 (rat, oral), 15.9/1.2 (rat,
i.v.), 79/1.9 (rat, i.p.), 188/2.27
(mouse, oral), 21/1.32 (mouse,
i.v.), 51.6/1.71 (mouse, i.p.)

Heart, CNS

Primidone

> 436/2.64

Gastrointestinal 1500/3.18 (rat, oral), 280/2.45

(mouse, oral)

Brain, blood

Haloperidol 18.8/1.27 Heart, jaw, brain 128/2.11 (rat, oral) Blood, CNS

Carbamazepine 118/2.07 Heart, jaw, developmental 1957/3.29 (rat, oral) Reproductive system, blood,

nervous system

Desipramine HCl 116/2.06 Heart, jaw 871/2.94 (rat, oral), 29/1.46 (rat,

i.v.), 48/1.68 (rat, i.p.), 448/2.65
(mouse, oral), 22/1.34 (mouse,
i.v.), 85/1.93 (mouse, i.p.)

CNS, heart

trans -2-
Phenylcyclopropylamine
(tranylcypromine)

340/2.53 Heart, jaw, brain Unknown Heart, CNS

Dopamine 228/2.36 Heart, jaw, brain Unknown Heart, CNS