Biomedical Engineering Reference
In-Depth Information
Cycloheximide
8.4/0.93
Teratogenic, liver, brain,
gastrointestinal
2/0.3 (rat, oral), 2/0.3 (rat, i.v.),
3.7/0.57 (rat, i.p.), 133/2.12
(mouse, oral), 150/2.18 (mouse,
i.v.), 100/2.0 (mouse, i.p.)
Mutagenic, respiratory, CNS,
kidney, liver
Tamoxifen
17/1.23
Liver, eye, CNS
218/2.33 (mouse, oral), 1190/3.08
(rat, oral), 62.50/1.8 (rat, i.v.),
575/2.76 (rat, i.p.), 62.5/1.8
(mouse, i.v.), 3100/3.49
(mouse, i.p.)
Carcinogenic, ocular, induce
hypertrophy, reproductive,
mutagenic
Clomiphene
4.5/0.65
Liver, red blood cells,
gastrointestinal, brain
5750/3.76 (rat, oral), 1400/3.15
(mouse, oral)
Reproductive system
Flavopiridol
2.2/0.34
Teratogenic, liver,
gastrointestinal
3/0.48 (rat, oral maximum
tolerance dose)
Teratogenic, liver,
gastrointestinal, spleen, bone
marrow
Thalidomide
103.2/2.01
Teratogenic, liver,
gastrointestinal
113/2.05 (rat, oral), 2000/3.30
(mouse, oral)
Teratogenic, liver,
gastrointestinal
SU5416
1.0/0
Teratogenic, liver,
cardiovascular
Unknown
Unknown
Col-3
1.0/0
Teratogenic, liver,
gastrointestinal
75/1.87 (rat, oral)
Gastrointestinal, kidney, liver,
bone marrow
Ethanol
11,180/4.0
Teratogenic, neuronal,
craniofacial
7,000/3.8 (rat, oral), 1440/3.16
(rat, i.v.), 360/2.56 (rat, i.p.)
Liver, teratogenic, neuronal,
craniofacial
Nicotine
161.7/2.21
Liver, kidney, brain,
cardiovascular,
teratogenic
188/2.27 (rat, oral), 1.0/0.00
(rat, i.v.), 30/1.48 (rat, i.p.),
24/1.38 (mouse, oral)
Liver, kidney, neurotoxicity,
respiratory, cardiovascular
Caffeine
108/2.03
Behavioral, neuronal
127/2.1 (mouse, i.p.), 247/2.39
(rat, oral), 137/2.14 (mouse,
oral)
Behavioral, neuronal
Pentylenetetrazole
> 276/2.44
Liver
140/2.15 (rat, oral), 88/1.94
(mouse, oral)
CNS, cardiovascular
( continued )
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