Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 30

Table 3.1 ( Continued )

Zebrafish Mammalian models

LC 50 /log
LC 50 (mg/L)

Compound

Target organs LD 50 /log LD 50 (mg/kg) Target organs

Chlorambucil 9.1/0.96 Gastrointestinal, liver,

pancreas

17.7/1.25 (mouse, oral) Carcinogenic, mutagenic, bone

marrow suppression,
gastrointestinal, liver

5-Azacytidine 6100/3.79 Teratogenic, liver,

gastrointestinal

500/2.7 (mouse, oral), 229/2.36
(mouse, i.v.), 68/1.83
(mouse, i.p.)

Carcinogenic, teratogenic, liver,
gastrointestinal

Busulfan 61.5/1.79 Liver, gastrointestinal 120/2.08 (mouse, oral) Carcinogenic, bone marrow

depression

Aminonicotinamide 479.5/2.68 Teratogenic, liver,

gastrointestinal

35/1.54 (mouse, i.p.) Teratogenic, mutagenic, liver

Aphidicolin 10.14/1.00 Liver, kidney Unknown Carcinogenic

Furazolidone 45/1.65 Teratogenic, liver, brain 300/2.48 (mouse, i.p.), 1782/3.25

(mouse, oral), 2336/3.37 (rat,
oral)

Carcinogenic, mutagenic,
teratogenic, liver, CNS

2-Chlorodeoxyadenosine 114.4/2.06 Gastrointestinal, kidney,

teratogenic

Unknown Immunotoxic, gastrointestinal,

kidney, developmental

Topotecan 11.45/1.06 Teratogenic, liver Unknown Teratogenic, mutagenic

Mechlorethamine 96.5/1.98 Liver, teratogenic 10/1 (rat, oral), 100/2.0 (human,

skin)

Carcinogenic, bone marrow
suppression, liver, teratogenic

Ifosfamide 1174/3.06 Liver, kidney, teratogenic 1005/3.0 (mouse, oral),

143/2.16 (rat, oral), 190/2.28
(rat, i.v.), 140/2.15 (rat, i.p.),
338/2.53 (mouse, i.v.),
397/2.60 (mouse, i.p.)

Carcinogenic, mutagenic, liver,
kidney