Biomedical Engineering Reference
In-Depth Information
Cyclophosphamide
650/2.8
Developmental, liver
315/2.5 (mouse, oral), 160/2.2
(rat, oral), 148/2.17 (rat, i.v.),
40/1.6 (rat, i.p.), 140/2.15
(mouse, i.v.), 315/2.5
(mouse, i.p.)
Teratogenic, liver
Methotrexate
454/2.6
Gastrointestinal, liver,
kidney, teratogenic
180/2.3 (rat, oral), 15/1.18
(rat, i.p.), 94/1.97 (mouse, i.p.)
Gastrointestinal, liver,
teratogenic
Actinomycin D
50/1.7
Liver, gastrointestinal,
developmental
7.2/0.86 (rat, oral)
Mutagenic, respiratory, liver,
developmental
Bleomycin
272.9/2.44
Heart, liver,
gastrointestinal,
smaller brain
168/2.23 (rat, i.p.)
Pulmonary, teratogenic
Melphalan
152.5/2.18
Gastrointestinal, liver,
pancreas
13/1.11 (rat, oral)
Carcinogenic, mutagenic, bone
marrow suppression,
gastrointestinal, liver
Carboplatin
185.6/2.27
Liver, kidney
118/2.07 (mouse, i.p.), 343/2.54
(rat, oral), 61/1.79 (rat, i.v.),
89.4/1.95 (mouse, i.v.)
Bone marrow depression, kidney,
liver, hearing loss, neurotoxicity
Cisplatin
3/0.48
Liver, kidney,
teratogenic
20/1.3 (rat, oral), 8/0.90 (rat, i.v.),
6.4/0.81 (rat, i.p.), 327/2.51
(mouse, oral), 11/1.04 (mouse,
i.v.), 6.6/0.82 mouse, i.p.)
Bone marrow depression, kidney,
liver, hearing loss, neurotoxicity
Hydroxyurea
12160/4.08
Teratogenic,
gastrointestinal
2000/3.3 (dog, oral)
Teratogenic, gastrointestinal,
mutagenic, bone marrow
depression
Thymidine
36300/4.56
Teratogenic, liver
2512/3.4 (mouse, i.p.)
Mutagenic, possible effects on
fetus
Etoposide
176.7/2.25
Developmental,
gastrointestinal
215/2.33 (mouse, oral)
Carcinogenic, mutagenic,
developmental, gastrointestinal
( continued )
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