Biomedical Engineering Reference
In-Depth Information
Table 10.5
Published Clinical Studies on ALA- and MAL-PDT for Photorejuvenation (
Continued
)
Location of
Photodamage/
Study Design
Incubation
Period (hr)
Light Source
(Emission
λ
, nm)
Reference
ALA Preparation
# Patients
Response
Follow-up (mo)
Alster (179) (2005)
20% Solution
Split-face
comparison, IPL
vs. ALA-IPL
1-3
10
IPL (500-1200)
ALA-IPL-treated
side showed
greater
improvement
6
Dover (167) (2005)
20% Solution
Split-face
comparison,
IPL vs. ALA-IPL
(5 treatment
sessions)
0.5-1
20
IPL (515-1200)
Greater improve-
ment in ALA-IPL
over IPL only for
global photoaging,
pigmentation, and
fi ne lines only
1
Key (183) (2005)
20% Solution
Face, subpurpuric
doses of PDL
1
12
PDL (585)
Improvement in
majority of
photodamage
parameters with
ALA-PDL; no
improvement with
PDL alone
1
Lowe (175) (2005)
5-20% Cream
Forearm, periorbital
0.5-2
6
Red light (633)
Mild improvement
noted in
photoaging
0.25
Marmur (180) (2005)
20% Solution
Split-face compari-
son, IPL vs.
ALA-IPL (1
treatment)
1
7
IPL
Microscopic
changes demon-
strated greater
type I collagen on
ALA-IPL side
N/A
Gold (169) (2006)
20% Solution
Split-face compari-
son, IPL vs.
ALA-IPL
(3 treatment
sessions)
0.5-1
16
IPL (550/570 cutoff
fi lters-1200)
ALA-IPL results
superior to IPL
alone
1-3
