Biomedical Engineering Reference
In-Depth Information
Serrano (181) (2009)
1-2% Gel
Multiple applica-
tion, low
concentration
ALA-PDT to face,
neck, hands (3
treatment
sessions)
0.5-1
8/26 Patients with
photoaging; 18/26
treated for acne,
vitiligo
IPL (530-1200) or
yellow-red lamp
(550-630)
90% of cases
with hyper-
pigmentation
improvement;
erythema
(85%), skin
texture (100%)
6
Park (176) (2010)
20% cream
2 ALA-PDT at 1-mo
interval, repeated
(2 sessions) after 1
mo if required
4
14 with 1-3 AKs on
the face and
photodamage
Red light
(580-740 nm),
dose of 100 J/cm
2
,
100 mW/cm
2
82.6% CR of
Aks 1 mo after last
treatment,
microscopic
analysis showed
increased
expression of
type I and III
procollagen,
reduced elastotic
material,
decreased levels of
matrix metallo-
proteinases-1,-3,
and -12
1 mo after last
treatment
Clementoni (184)
(2010)
20% Solution
Face, pretreatment
with a micronee-
dle roller followed
by ALA-PDT
1
21
IPL (560 cutoff
fi lter-1200) and
red LED light
(630 nm)
Improvement in
photodamage
markers, including
fi ne lines, mottled
pigmentation,
sallowness, tactile
roughness, and
telangiectasias
6
Xi et al. (182) (2011)
5% and 10% Cream
Face, split-face
comparison,
IPL vs. ALA-IPL
(3 treatment
sessions) in
Chinese patients
1
26
IPL (560 and
590 cutoff
fi lter-1200 nm)
Greater improve-
ment in global
score for photo-
aging, fi ne lines,
and coarse
wrinkles. PIH was
higher on the
ALA-IPL PDT side
(22% vs.
15% on the
IPL-only side)
2
(
Continued
)
